Title : Xanthorrhizol exhibits antiproliferative activity on MCF-7 breast cancer cells via apoptosis induction.

Pub. Date : 2006 Nov-Dec

PMID : 17201174






2 Functional Relationships(s)
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1 The level of p53 was greatly increased, whilst PARP-1 was cleaved to 85 kDa subunits, following the treatment with xanthorrhizol at a dose-dependent manner. xanthorrhizol poly(ADP-ribose) polymerase 1 Homo sapiens
2 These results, thereby, suggest that xanthorrhizol has antiproliferative effects on MCF-7 cells by inducing apoptosis through the modulation of bcl-2, p53 and PARP-1 protein levels. xanthorrhizol poly(ADP-ribose) polymerase 1 Homo sapiens