Pub. Date : 2007 Jan
PMID : 17200183
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis. | Bleomycin | elastase, neutrophil expressed | Mus musculus |
| 2 | In neutrophil elastase-null mice, biochemical and morphological characteristics of pulmonary fibrosis were attenuated for at least 60 days after bleomycin administration despite a typical response to bleomycin as evidenced by assessment of indices of DNA and cell damage. | Bleomycin | elastase, neutrophil expressed | Mus musculus |
| 3 | In neutrophil elastase-null mice, biochemical and morphological characteristics of pulmonary fibrosis were attenuated for at least 60 days after bleomycin administration despite a typical response to bleomycin as evidenced by assessment of indices of DNA and cell damage. | Bleomycin | elastase, neutrophil expressed | Mus musculus |
| 4 | Neutrophil burden of bleomycin-treated wild-type and neutrophil elastase-null mice was comparable, and marked neutrophilic alveolitis was manifest in bleomycin-treated neutrophil elastase-null mice. | Bleomycin | elastase, neutrophil expressed | Mus musculus |
| 5 | Neutrophil burden of bleomycin-treated wild-type and neutrophil elastase-null mice was comparable, and marked neutrophilic alveolitis was manifest in bleomycin-treated neutrophil elastase-null mice. | Bleomycin | elastase, neutrophil expressed | Mus musculus |
| 6 | An absence of immunostaining for active transforming growth factor (TGF)-beta in lung tissue from bleomycin-treated neutrophil elastase-null mice suggested a defect in TGF-beta activation, which was confirmed by biochemical assessment of TGF-beta levels in bronchoalveolar lavage fluid and lung tissue. | Bleomycin | elastase, neutrophil expressed | Mus musculus |