Title : Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells.

Pub. Date : 2007 Mar 23

PMID : 17200122






1 Functional Relationships(s)
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1 This was demonstrated by 1) oxysterol-induced expression of the Hh target genes Gli-1 and Patched, 2) oxysterol-induced activation of a luciferase reporter driven by a multimerized Gli-responsive element, 3) inhibition of oxysterol effects by the hedgehog pathway inhibitor, cyclopamine, and 4) unresponsiveness of Smoothened-/- mouse embryonic fibroblasts to oxysterols. cyclopamine GLI-Kruppel family member GLI1 Mus musculus