Title : Acetylcholinesterase: converting a vulnerable target to a template for antidotes and detection of inhibitor exposure.

Pub. Date : 2007 Apr 20

PMID : 17196318






6 Functional Relationships(s)
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1 Accordingly, "Oxime-assisted Catalysis" by AChE provides a potential means for catalyzing the hydrolysis of organophosphates in plasma prior to their reaching the cellular target site. Organophosphates acetylcholinesterase (Cartwright blood group) Homo sapiens
2 In turn, AChE, when conjugated with organophosphate, is employed as a template for "click-chemistry, freeze-frame" synthesis of new nucleophilic reactivating agents that could potentially prove useful in AChE reactivation at the target site as well as in catalytic scavenging of organophosphates in plasma. Organophosphates acetylcholinesterase (Cartwright blood group) Homo sapiens
3 In turn, AChE, when conjugated with organophosphate, is employed as a template for "click-chemistry, freeze-frame" synthesis of new nucleophilic reactivating agents that could potentially prove useful in AChE reactivation at the target site as well as in catalytic scavenging of organophosphates in plasma. Organophosphates acetylcholinesterase (Cartwright blood group) Homo sapiens
4 In turn, AChE, when conjugated with organophosphate, is employed as a template for "click-chemistry, freeze-frame" synthesis of new nucleophilic reactivating agents that could potentially prove useful in AChE reactivation at the target site as well as in catalytic scavenging of organophosphates in plasma. Organophosphates acetylcholinesterase (Cartwright blood group) Homo sapiens
5 In turn, AChE, when conjugated with organophosphate, is employed as a template for "click-chemistry, freeze-frame" synthesis of new nucleophilic reactivating agents that could potentially prove useful in AChE reactivation at the target site as well as in catalytic scavenging of organophosphates in plasma. Organophosphates acetylcholinesterase (Cartwright blood group) Homo sapiens
6 Finally, substituted AChE molecules can be conjugated to fluorophores giving rise to shifts in emission spectra for detection of dispersed organophosphates. Organophosphates acetylcholinesterase (Cartwright blood group) Homo sapiens