Title : Effects of acetylcholinesterase gene silencing on its activity in cultured human skeletal muscle.

Pub. Date : 2006

PMID : 17192616






2 Functional Relationships(s)
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1 Our aim was to find out how the temporal profile of the AChE mRNA decrease is reflected at the level of AChE activity under normal conditions and after inhibition of preexisting AChE by diisopropyl phosphorofluoridate (DFP).AChE activity was determined at selected time intervals after siRNA treatment in both myoblast homogenates and in culture medium to follow the effects of siRNA treatment at the level of intracellular AChE synthesis and at the level of AChE secreted from the cell. Isoflurophate acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Our aim was to find out how the temporal profile of the AChE mRNA decrease is reflected at the level of AChE activity under normal conditions and after inhibition of preexisting AChE by diisopropyl phosphorofluoridate (DFP).AChE activity was determined at selected time intervals after siRNA treatment in both myoblast homogenates and in culture medium to follow the effects of siRNA treatment at the level of intracellular AChE synthesis and at the level of AChE secreted from the cell. Isoflurophate acetylcholinesterase (Cartwright blood group) Homo sapiens