Title : Biosynthesis of new indigoid inhibitors of protein kinases using recombinant cytochrome P450 2A6.

Pub. Date : 2005 Jan

PMID : 17191919






1 Functional Relationships(s)
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1 Indirubin-5-5"-dicarbonitrile was also modified to the corresponding 3"-oxime, which had low specificity but showed very high inhibition of all three kinases with IC50 values of 5, 13, and 10 nM towards GSK-3alpha/beta, CDK1, and CDK5, respectively. indirubin-5-5"-dicarbonitrile cyclin dependent kinase 1 Homo sapiens