Title : Biosynthesis of new indigoid inhibitors of protein kinases using recombinant cytochrome P450 2A6.

Pub. Date : 2005 Jan

PMID : 17191919






1 Functional Relationships(s)
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1 In this work, a new disubstituted indigoid generation system was developed with a tryptophanase-deficient Escherichia coli strain as a host to express the human cytochrome P450 2A6 mutant L240C/N297Q, which catalyzes the oxidation of indole to isatin and indoxyl, which in turn react to generate indigoids. Isatin cytochrome P450 family 2 subfamily A member 6 Homo sapiens