Pub. Date : 2007 Jan 23
PMID : 17184774
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Diphenyleneiodonium induces ROS-independent p53 expression and apoptosis in human RPE cells. | ros | tumor protein p53 | Homo sapiens |
| 2 | ROS have been implicated as a key factor in the activation of p53 by many chemotherapeutic drugs. | ros | tumor protein p53 | Homo sapiens |
| 3 | We conclude that DPI induces the expression of p53 by ROS-independent mechanism in ARPE-19 cells, and renders cells sensitive to drug-induced apoptosis by induction of p53 expression. | ros | tumor protein p53 | Homo sapiens |