Pub. Date : 2007 Feb
PMID : 17179942
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of budesonide on P-glycoprotein expression in intestinal cell lines. | Budesonide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Since glucocorticoids, such as budesonide, are frequently used during inflammatory bowel disease we investigated how budesonide influences P-gp expression in different intestinal cell lines. | Budesonide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | KEY RESULTS: Budesonide showed an induction of P-gp in LS180 cells and a down-regulation in Caco-2 cells. | Budesonide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | In PXR-transfected Caco-2 cells the budesonide-mediated down-regulation of P-gp was abolished. | Budesonide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | CONCLUSIONS AND IMPLICATIONS: Budesonide has the potential to influence MDR1 expression in vitro. | Budesonide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | In LS180 cells, the induction of MDR1 by budesonide probably is mediated via PXR. | Budesonide | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | Further studies are required to evaluate how budesonide alters P-gp expression in vivo. | Budesonide | ATP binding cassette subfamily B member 1 | Homo sapiens |