Title : Effects of budesonide on P-glycoprotein expression in intestinal cell lines.

Pub. Date : 2007 Feb

PMID : 17179942






7 Functional Relationships(s)
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1 Effects of budesonide on P-glycoprotein expression in intestinal cell lines. Budesonide ATP binding cassette subfamily B member 1 Homo sapiens
2 Since glucocorticoids, such as budesonide, are frequently used during inflammatory bowel disease we investigated how budesonide influences P-gp expression in different intestinal cell lines. Budesonide ATP binding cassette subfamily B member 1 Homo sapiens
3 KEY RESULTS: Budesonide showed an induction of P-gp in LS180 cells and a down-regulation in Caco-2 cells. Budesonide ATP binding cassette subfamily B member 1 Homo sapiens
4 In PXR-transfected Caco-2 cells the budesonide-mediated down-regulation of P-gp was abolished. Budesonide ATP binding cassette subfamily B member 1 Homo sapiens
5 CONCLUSIONS AND IMPLICATIONS: Budesonide has the potential to influence MDR1 expression in vitro. Budesonide ATP binding cassette subfamily B member 1 Homo sapiens
6 In LS180 cells, the induction of MDR1 by budesonide probably is mediated via PXR. Budesonide ATP binding cassette subfamily B member 1 Homo sapiens
7 Further studies are required to evaluate how budesonide alters P-gp expression in vivo. Budesonide ATP binding cassette subfamily B member 1 Homo sapiens