Title : Statin-induced Ras activation integrates the phosphatidylinositol 3-kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast differentiation.

Pub. Date : 2007 Feb 16

PMID : 17179158






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We provide, as a mechanism of this cross-talk, the first evidence that lovastatin stimulates rapid activation of Ras, which associates with and activates PI3K in the plasma membrane, which in turn regulates Akt and Erk1/2 to induce BMP-2 expression for osteoblast differentiation. Lovastatin AKT serine/threonine kinase 1 Homo sapiens