Title : Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma.

Pub. Date : 2006 Dec 15

PMID : 17178880






5 Functional Relationships(s)
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Protein Name
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1 Here, we show that GPCR ligands prostaglandin E2 (PGE2) and bradykinin (BK) activate EGFR signaling. Dinoprostone epidermal growth factor receptor Homo sapiens
2 Here, we show that GPCR ligands prostaglandin E2 (PGE2) and bradykinin (BK) activate EGFR signaling. Dinoprostone epidermal growth factor receptor Homo sapiens
3 PGE2 and BK triggered EGFR signaling by increasing selective autocrine release of transforming growth factor-alpha (TGF-alpha). Dinoprostone epidermal growth factor receptor Homo sapiens
4 Inhibition of tumor necrosis factor-alpha-converting enzyme abrogated BK- or PGE2-mediated activation of EGFR signaling. Dinoprostone epidermal growth factor receptor Homo sapiens
5 Both PGE2 and BK stimulated head and neck squamous cell carcinoma (HNSCC) invasion via EGFR. Dinoprostone epidermal growth factor receptor Homo sapiens