Title : Glycosylation mediates up-regulation of a potent antiangiogenic and proatherogenic protein, thrombospondin-1, by glucose in vascular smooth muscle cells.

Pub. Date : 2007 Feb 23

PMID : 17178709






1 Functional Relationships(s)
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1 Specific inhibitors of glutamine: fructose 6-phosphate amidotransferase (GFAT), an enzyme controlling the hexosamine pathway, as well as direct inhibitors of protein glycosylation efficiently inhibited TSP-1 transcription and the activity of a TSP-1 promoter-reporter construct stimulated by high glucose. Hexosamines glutamine--fructose-6-phosphate transaminase 1 Homo sapiens