Pub. Date : 2006 Dec
PMID : 17178268
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Methadone is a substrate for the P-glycoprotein transporter, encoded by the ABCB1 gene, which regulates central nervous system exposure. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | This retrospective study aimed to investigate the influence of ABCB1 genetic variability on methadone dose requirements. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | ABCB1 genetic variability influenced daily methadone dose requirements, such that subjects carrying 2 copies of the wild-type haplotype required higher doses compared with those with 1 copy and those with no copies (98.3 +/- 10.4, 58.6 +/- 20.9, and 55.4 +/- 26.1 mg/d, respectively; P = .029). | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | CONCLUSION: Although ABCB1 genetic variability is not related to the development of opioid dependence, identification of variant haplotypes may, after larger prospective studies have been performed, provide clinicians with a tool for methadone dosage individualization. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |