Pub. Date : 2006 Dec 26
PMID : 17176100
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of the protein phosphatase calcineurin (CaN), which has been implicated in the FK506-mediated blockade of T cell proliferation, was shown to involve a gain of function in the FKBP12/FK506 complex. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 4 | Homo sapiens |
| 2 | The different capacities of FK506/FKBP complexes to affect CaN activity are partially caused by substitutions corresponding to the amino acid side chains K34 and I90 of FKBP12. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 4 | Homo sapiens |
| 3 | Only the FK506 complexes of FKBP12, FKBP12.6, and FKBP51 showed high affinity to CaN; small interfering RNA against these FKBP allowed defining the contribution of individual FKBP in an NFAT reporter gene assay. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 4 | Homo sapiens |