Pub. Date : 2007 Feb 14
PMID : 17173892
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oxidative renal damage in pyelonephritic rats is ameliorated by montelukast, a selective leukotriene CysLT1 receptor antagonist. | montelukast | cysteinyl leukotriene receptor 1 | Rattus norvegicus |
| 2 | The present study aimed to investigate the possible protective effect of montelukast, a selective antagonist of cysteinyl leukotriene receptor 1 (leukotriene CysLT1), against Escherichia coli-induced oxidative injury and scarring in renal tissue. | montelukast | cysteinyl leukotriene receptor 1 | Rattus norvegicus |
| 3 | Leukotriene CysLT1 receptor antagonist montelukast reversed all these biochemical indices, as well as histopathological alterations, that were induced by acute pyelonephritis. | montelukast | cysteinyl leukotriene receptor 1 | Rattus norvegicus |
| 4 | It seems likely that montelukast protects kidney tissue by inhibiting neutrophil infiltration, balancing oxidant-antioxidant status, and regulating the generation of inflammatory mediators suggesting a future role for leukotriene CysLT1 receptor antagonists in the treatment of pyelonephritis. | montelukast | cysteinyl leukotriene receptor 1 | Rattus norvegicus |