Pub. Date : 1975
PMID : 171710
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | These findings are suggestive of a second messenger role of cyclic AMP in the beta-adrenoreceptor-mediated actions of catecholamines on myocardial contractile force and relaxation, in which Ca2+ would serve as a third messenger and be subject, respectively, to more effective removal from its binding sites on troponin. | Catecholamines | adenine phosphoribosyltransferase | Homo sapiens |
| 2 | An alternative interpretation regards Ca2+ and cyclic AMP as interdependent twin second messengers in the catecholamine-induced inotropism. | Catecholamines | adenine phosphoribosyltransferase | Homo sapiens |
| 3 | Since the physiological meaning of the reported effects of cyclic AMP on isolated myocardial membrane preparations is far from established an instances of a dissociation between the effects of catecholamines on myocardial contractile force and cyclic AMP levels have been observed, there is still room for hypotheses that relegate cyclic AMP to a nonobligatory, at most, supportive role in the action of the catecholamines on cardiac contraction. | Catecholamines | adenine phosphoribosyltransferase | Homo sapiens |
| 4 | Since the physiological meaning of the reported effects of cyclic AMP on isolated myocardial membrane preparations is far from established an instances of a dissociation between the effects of catecholamines on myocardial contractile force and cyclic AMP levels have been observed, there is still room for hypotheses that relegate cyclic AMP to a nonobligatory, at most, supportive role in the action of the catecholamines on cardiac contraction. | Catecholamines | adenine phosphoribosyltransferase | Homo sapiens |