Title : p53 and p73 display common and distinct requirements for sequence specific binding to DNA.

Pub. Date : 2007

PMID : 17170001






2 Functional Relationships(s)
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1 Comparing p53 and p73beta proteins, our data show that zinc chelation by EDTA is significantly more detrimental to the ability of p73beta than of p53 to bind DNA, most likely due to the greater effect that the loss of zinc has on the conformation of the DNA-binding domain of p73. Edetic Acid tumor protein p53 Homo sapiens
2 Comparing p53 and p73beta proteins, our data show that zinc chelation by EDTA is significantly more detrimental to the ability of p73beta than of p53 to bind DNA, most likely due to the greater effect that the loss of zinc has on the conformation of the DNA-binding domain of p73. Edetic Acid tumor protein p53 Homo sapiens