Title : 7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes.

Pub. Date : 2007 Jun

PMID : 17166882






2 Functional Relationships(s)
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1 Using knockout mice for Cyp1a1, Cyp1a2 and Cyp1b1, we showed that the major CYP1 enzymes that metabolize DBC are CYP1A1 in beta-naphthoflavone (BNF)-induced liver, CYP1A2 in non-induced liver, CYP1B1 and CYP1A1 in induced lung and none in non-induced lung. 7H-dibenzo(c,g)carbazole cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus
2 Using knockout mice for Cyp1a1, Cyp1a2 and Cyp1b1, we showed that the major CYP1 enzymes that metabolize DBC are CYP1A1 in beta-naphthoflavone (BNF)-induced liver, CYP1A2 in non-induced liver, CYP1B1 and CYP1A1 in induced lung and none in non-induced lung. 7H-dibenzo(c,g)carbazole cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus