Pub. Date : 2007 Jan 30
PMID : 17166674
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Controversial results about the involvement of CYP 1A2 and oxidative stress in tacrine-induced hepatotoxicity have been described by the different research groups. | Tacrine | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 2 | The fact that fluvoxamine, a potent cytochrome P450 (CYP) 1A2 inhibitor, reduced tacrine toxicity and the expression of the CYP 1A2 gene was maintained in gel entrapped hepatocytes, but not in hepatocyte monolayers, could illustrate a close association between CYP 1A2 expression levels and tacrine toxicity. | Tacrine | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |