Title : Inhibition of human liver microsomal cytochrome P450 activities by adefovir and tenofovir.

Pub. Date : 2006 Dec

PMID : 17162464






1 Functional Relationships(s)
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1 Adefovir and its prodrug inhibited CYP2C9 at concentrations below 100 microM; inhibition by adefovir was of the uncompetitive (at the lower inhibitor concentrations) or of the competitive nature with a Ki = 420 microM. adefovir cytochrome P450 family 2 subfamily C member 9 Homo sapiens