Title : PD98059 triggers G1 arrest and apoptosis in human leukemic U937 cells through downregulation of Akt signal pathway.

Pub. Date : 2007 Jan

PMID : 17161815






1 Functional Relationships(s)
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1 PD98059 also decreased the Cdk-2, Cdk-4, cyclin D1, and cyclin E expression, and increased high levels of the mitotic inhibitors p16(INIa), p21(Waf1), and p27(Kip1). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one cyclin D1 Homo sapiens