Title : Effects of statin treatment and withdrawal on angiotensin II-induced phosphorylation of p38 MAPK and ERK1/2 in cultured vascular smooth muscle cells.

Pub. Date : 2007 Feb 2

PMID : 17161379






2 Functional Relationships(s)
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1 Pretreatment with 1-3 microM simvastatin for 24h inhibited AII-mediated stimulation of ERK1/2 and p38 MAPK phosphorylation; without affecting the levels on non-phosphorylated MAPK. Simvastatin angiotensinogen Rattus norvegicus
2 Washout of simvastatin produced a rebound increase above control levels of AII-mediated phosphorylation of ERK1/2 and p38 MAPK. Simvastatin angiotensinogen Rattus norvegicus