Title : Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase.

Pub. Date : 2007

PMID : 17158155






2 Functional Relationships(s)
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1 Herein, we report the crystal structures of human deoxycytidine kinase (dCK) in complex with the L-nucleosides (-)-beta-2",3"-dideoxy-3"-thiacytidine (3TC)--an approved anti-human immunodeficiency virus (HIV) agent--and troxacitabine (TRO)--an experimental anti-neoplastic agent. troxacitabine potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens
2 Herein, we report the crystal structures of human deoxycytidine kinase (dCK) in complex with the L-nucleosides (-)-beta-2",3"-dideoxy-3"-thiacytidine (3TC)--an approved anti-human immunodeficiency virus (HIV) agent--and troxacitabine (TRO)--an experimental anti-neoplastic agent. troxacitabine potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens