Pub. Date : 2007 Jul
PMID : 17156920
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene. | Morphine | catechol-O-methyltransferase | Homo sapiens |
| 2 | We assessed joint effects of the OPRM1 and COMT genes in predicting morphine dose for cancer pain relief. | Morphine | catechol-O-methyltransferase | Homo sapiens |
| 3 | Results showed significant variation in morphine dose requirement by genotype groups: carriers of COMT Val/Val and Val/Met genotype required 63% and 23%, respectively, higher morphine dose compared to carriers of Met/Met genotype (p=0.02). | Morphine | catechol-O-methyltransferase | Homo sapiens |
| 4 | Results showed significant variation in morphine dose requirement by genotype groups: carriers of COMT Val/Val and Val/Met genotype required 63% and 23%, respectively, higher morphine dose compared to carriers of Met/Met genotype (p=0.02). | Morphine | catechol-O-methyltransferase | Homo sapiens |
| 5 | When we explored for joint effects, we found that carriers of the OPRM1 AA and COMT Met/Met genotype required the lowest morphine dose to achieve pain relief (87 mg/24 h; 95%CI=57,116) and those with neither Met/Met nor AA genotype needed the highest morphine dose (147 mg/24 h; 95%CI=100,180). | Morphine | catechol-O-methyltransferase | Homo sapiens |