Title : Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene.

Pub. Date : 2007 Jul

PMID : 17156920






5 Functional Relationships(s)
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1 Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene. Morphine catechol-O-methyltransferase Homo sapiens
2 We assessed joint effects of the OPRM1 and COMT genes in predicting morphine dose for cancer pain relief. Morphine catechol-O-methyltransferase Homo sapiens
3 Results showed significant variation in morphine dose requirement by genotype groups: carriers of COMT Val/Val and Val/Met genotype required 63% and 23%, respectively, higher morphine dose compared to carriers of Met/Met genotype (p=0.02). Morphine catechol-O-methyltransferase Homo sapiens
4 Results showed significant variation in morphine dose requirement by genotype groups: carriers of COMT Val/Val and Val/Met genotype required 63% and 23%, respectively, higher morphine dose compared to carriers of Met/Met genotype (p=0.02). Morphine catechol-O-methyltransferase Homo sapiens
5 When we explored for joint effects, we found that carriers of the OPRM1 AA and COMT Met/Met genotype required the lowest morphine dose to achieve pain relief (87 mg/24 h; 95%CI=57,116) and those with neither Met/Met nor AA genotype needed the highest morphine dose (147 mg/24 h; 95%CI=100,180). Morphine catechol-O-methyltransferase Homo sapiens