Title : Involvement of TRPV1-dependent and -independent components in the regulation of vagally induced contractions in the mouse esophagus.

Pub. Date : 2007 Feb 5

PMID : 17156774






4 Functional Relationships(s)
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1 In a recent study, similar but also different effects of capsaicin and piperine on TRPV1 were demonstrated. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
2 Ruthenium red (10 microM; a non-selective blocker of transient receptor potential cation channels) and SB-366791 (10 microM; a novel selective antagonist of TRPV1) blocked the inhibitory effect of capsaicin but not that of piperine. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
3 Desensitization of TRPV1 in the mouse esophagus by in vitro pretreatment with capsaicin failed to affect the inhibitory effect of piperine, whereas the piperine effect was cross-desensitized by capsaicin pretreatment in rat and hamster esophagi. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
4 Desensitization of TRPV1 in the mouse esophagus by in vitro pretreatment with capsaicin failed to affect the inhibitory effect of piperine, whereas the piperine effect was cross-desensitized by capsaicin pretreatment in rat and hamster esophagi. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus