Pub. Date : 2007 Mar 1
PMID : 17152074
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Upregulation of AKT1 protein expression in forskolin-stimulated macrophage: evidence from ChIP analysis that CREB binds to and activates the AKT1 promoter. | Colforsin | cAMP responsive element binding protein 1 | Homo sapiens |
| 2 | Recently, we reported that silencing CREB gene expression by RNAi significantly attenuates forskolin-induced activation of Akt1. | Colforsin | cAMP responsive element binding protein 1 | Homo sapiens |
| 3 | Forskolin-dependent Akt1 synthesis was abolished by pretreating the cells with CREB-directed dsRNA as demonstrated at both the message and protein level, as well as by determining the synthesis of [(35)S]-labeled Akt1 protein. | Colforsin | cAMP responsive element binding protein 1 | Homo sapiens |
| 4 | In conclusion, we show here for the first time transcriptional upregulation of Akt1 by CREB, based upon Akt1 protein synthesis and its modulation by transitional and translational inhibitors in forskolin-stimulated cells, Akt1 protein. | Colforsin | cAMP responsive element binding protein 1 | Homo sapiens |