Title : Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1.

Pub. Date : 2007 May 24

PMID : 17146434






1 Functional Relationships(s)
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1 In the human dedifferentiated liposarcoma cell line (LS141) and the p53 wild-type HCT116 cells, Nutlin-3a induced downregulation of E2F1 and this effect appeared to be proteasome dependent. nutlin 3 tumor protein p53 Homo sapiens