Title : A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species.

Pub. Date : 2006 Dec 1

PMID : 17145881






3 Functional Relationships(s)
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1 Importantly, TW-37 unveiled an unexpected role of the MAPK pathway in the control of reactive oxygen species (ROS). Reactive Oxygen Species mitogen-activated protein kinase 1 Homo sapiens
2 Importantly, TW-37 unveiled an unexpected role of the MAPK pathway in the control of reactive oxygen species (ROS). Reactive Oxygen Species mitogen-activated protein kinase 1 Homo sapiens
3 Our results suggest that this MAPK-dependent ROS/p53 feedback loop is a point of vulnerability of melanoma cells that can be exploited for rational drug design. Reactive Oxygen Species mitogen-activated protein kinase 1 Homo sapiens