Title : Glucosamine-induced increase in Akt phosphorylation corresponds to increased endoplasmic reticulum stress in astroglial cells.

Pub. Date : 2007 Apr

PMID : 17136481






3 Functional Relationships(s)
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1 Glucosamine-induced increase in Akt phosphorylation corresponds to increased endoplasmic reticulum stress in astroglial cells. Glucosamine AKT serine/threonine kinase 1 Homo sapiens
2 Herein, we investigate the effects of increased HBP flux on Akt activation in a human astroglial cells line using glucosamine, a compound commonly used to mimic hyperglycemic conditions by increasing HBP flux. Glucosamine AKT serine/threonine kinase 1 Homo sapiens
3 Cellular treatment with 8 mM glucosamine resulted in a 96.8% +/- 24.6 increase in Akt phosphorylation after 5 h of treatment that remained elevated throughout the 9-h time course. Glucosamine AKT serine/threonine kinase 1 Homo sapiens