Title : A novel copper complex of 3-benzoyl-alpha methyl benzene acetic acid with antitumor activity mediated via cyclooxygenase pathway.

Pub. Date : 2007 Feb 15

PMID : 17131340






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Expression of COX-2 is detectable in 75% of PCs among which 50% showed overexpression, suggesting the importance of COX-2 enzyme and its metabolic product prostaglandin E2 (PGE(2)) in PC. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Expression of COX-2 is detectable in 75% of PCs among which 50% showed overexpression, suggesting the importance of COX-2 enzyme and its metabolic product prostaglandin E2 (PGE(2)) in PC. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 The molecular modeling of FPA-306 in the COX-2 active site showed that FPA-306 is potentially able to inhibit the activity of enzyme by blocking the active site, thereby resulting in decreased PGE(2) production. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens