Pub. Date : 2006 Sep
PMID : 17122961
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Histamine induces interleukin-6 expression in the human synovial sarcoma cell line (SW982) through the H1 receptor. | Histamine | interleukin 6 | Homo sapiens |
| 2 | Histamine (EC50 = 1.8 +/- 1.1 microM) stimulated the release of IL-6 that was attenuated by selective H1 antagonists. | Histamine | interleukin 6 | Homo sapiens |
| 3 | The PKC inhibitor, GF1090203X, blocked the histamine stimulated IL-6 release. | Histamine | interleukin 6 | Homo sapiens |
| 4 | CONCLUSION: We conclude that histamine stimulates IL-6 release from SW982 cells by binding to the H1 receptor and this is coupled to the PI/PKC signal transduction pathway. | Histamine | interleukin 6 | Homo sapiens |