Title : CCK-B (gastrin) receptor regulates gastric histamine release and acid secretion.

Pub. Date : 1991 Jun

PMID : 1711780






3 Functional Relationships(s)
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1 Maximally G-(1-17) or CCK-(1-33) stimulated histamine release and acid secretion was unchanged by the CCK-A antagonist, while the gastrin antagonist induced a parallel and concentration-dependent decrease in stimulated histamine and acid secretion. Histamine gastrin Rattus norvegicus
2 We conclude that G-(1-17) and CCK-(1-33) stimulate histamine and acid secretion by a CCK-B (gastrin) receptor. Histamine gastrin Rattus norvegicus
3 The present results indicate that gastrin, at least in this species, stimulates acid secretion by releasing histamine. Histamine gastrin Rattus norvegicus