Title : Platelet-activating factor induces mediator release by human basophils primed with IL-3, granulocyte-macrophage colony-stimulating factor, or IL-5.

Pub. Date : 1991 Jul 1

PMID : 1711077






3 Functional Relationships(s)
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1 In this study we examined the effect of PAF upon the release of histamine and leukotriene (LT) C4 by basophils when added alone and in combination with different agonists and cytokines. Histamine PCNA clamp associated factor Homo sapiens
2 IL-1 beta-pretreated basophils released minimal amounts of histamine in response to PAF. Histamine PCNA clamp associated factor Homo sapiens
3 Thus, depending on the presence of IL-3, GM-CSF, or IL-5, PAF is a potent basophil agonist capable of inducing histamine release as well as de novo synthesis of LTC4. Histamine PCNA clamp associated factor Homo sapiens