Pub. Date : 2007 Feb
PMID : 17105867
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Many natural and synthetic steroids can also bind to the MR to produce agonist or antagonist effects. | Steroids | nuclear receptor subfamily 3 group C member 2 | Homo sapiens |
| 2 | Docking of steroids within the crystal structure of the ligand-binding domain of MR, together with trans-activation studies, revealed that the contacts between the 17beta-hydroxyl group of androgens and the Asn770, Cys942, and Thr945 residues of the ligand-binding cavity stabilize ligand binding complexes but are not strong enough to keep the receptor in its active state. | Steroids | nuclear receptor subfamily 3 group C member 2 | Homo sapiens |