Title : Prorenin and angiotensin-dependent renal vasoconstriction in type 1 and type 2 diabetes.

Pub. Date : 2006 Dec

PMID : 17093063






2 Functional Relationships(s)
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1 Active renin level in patients with diabetes (11.6 +/- 0.9 microU/ml) was significantly lower than in normal subjects (14.5 +/- 1.3 microU/ml; P < 0.05); despite this, the renal vascular response to captopril was much larger (82.9 +/- 11.5 versus 13.6 +/- 5.8 ml/min per 1.73 m(2); P < 0.01). Captopril renin Homo sapiens
2 The strong correlation between plasma prorenin concentration and the renovascular response to captopril in diabetes supports the hypothesis of a direct effect of prorenin, but the unanticipated high degree of correlation between plasma prorenin and active renin limits the conclusions that can be drawn. Captopril renin Homo sapiens