Title : Immunomodulatory drugs (IMiDs): a new treatment option for myelodysplastic syndromes.

Pub. Date : 2006 Oct

PMID : 17076650






6 Functional Relationships(s)
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1 Lenalidomide (CC-5013; Revlimid), a second generation IMiD, has shown significant erythropoietic activity in patients with lower risk MDS that have failed or are not candidates for recombinant erythropoietin treatment. Lenalidomide erythropoietin Homo sapiens
2 Lenalidomide (CC-5013; Revlimid), a second generation IMiD, has shown significant erythropoietic activity in patients with lower risk MDS that have failed or are not candidates for recombinant erythropoietin treatment. Lenalidomide erythropoietin Homo sapiens
3 Lenalidomide (CC-5013; Revlimid), a second generation IMiD, has shown significant erythropoietic activity in patients with lower risk MDS that have failed or are not candidates for recombinant erythropoietin treatment. Lenalidomide erythropoietin Homo sapiens
4 Unlike cytokine therapy, lenalidomide suppresses select MDS clones and enhances erythropoietin receptor signaling to restore erythropoiesis. Lenalidomide erythropoietin Homo sapiens
5 A phase III Intergroup trial (ECOG 2905) will test the capacity to potentiate erythropoietin response by comparing response to lenalidomide monotherapy to the combination of darbepoetin and lenalidomide in non-deletion 5q MDS patients. Lenalidomide erythropoietin Homo sapiens
6 A phase III Intergroup trial (ECOG 2905) will test the capacity to potentiate erythropoietin response by comparing response to lenalidomide monotherapy to the combination of darbepoetin and lenalidomide in non-deletion 5q MDS patients. Lenalidomide erythropoietin Homo sapiens