Title : Spinal muscular atrophy and therapeutic prospects.

Pub. Date : 2006

PMID : 17076267






2 Functional Relationships(s)
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1 Drugs such as valproic acid, phenylbutyrate, sodium butyrate, M344 and SAHA that mainly act as histone deacetylase inhibitors can mediate both: they stimulate the SMN2 gene transcription and/or restore the splicing pattern, thereby elevating the levels of FL-SMN2 protein. Valproic Acid survival of motor neuron 2, centromeric Homo sapiens
2 Drugs such as valproic acid, phenylbutyrate, sodium butyrate, M344 and SAHA that mainly act as histone deacetylase inhibitors can mediate both: they stimulate the SMN2 gene transcription and/or restore the splicing pattern, thereby elevating the levels of FL-SMN2 protein. Valproic Acid survival of motor neuron 2, centromeric Homo sapiens