Title : Substance P-induced histamine release from human basophils, skin and lung fragments: effect of nedocromil sodium and theophylline.

Pub. Date : 1990

PMID : 1707400






5 Functional Relationships(s)
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1 Substance P-induced histamine release from human basophils, skin and lung fragments: effect of nedocromil sodium and theophylline. Histamine tachykinin precursor 1 Homo sapiens
2 We compared histamine release induced by substance P with those obtained with classical secretagogues on human basophils, lung and skin fragments. Histamine tachykinin precursor 1 Homo sapiens
3 Substance P (10(-4) M) caused a noncytotoxic histamine release (about 10% of total) from basophils, lung and skin fragments. Histamine tachykinin precursor 1 Homo sapiens
4 Substance P-induced histamine release was always smaller than that obtained with optimal doses of anti-IgE, formyl-methionine phenylalanine or compound 48/80. Histamine tachykinin precursor 1 Homo sapiens
5 In contrast, it significantly inhibited anti-IgE- or substance P-induced histamine release from human lung. Histamine tachykinin precursor 1 Homo sapiens