Title : CYP121, CYP51 and associated redox systems in Mycobacterium tuberculosis: towards deconvoluting enzymology of P450 systems in a human pathogen.

Pub. Date : 2006 Dec

PMID : 17073780






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 These include the first characterized sterol 14alpha-demethylase P450 (CYP51), a known target for azole and triazole drugs in yeasts and fungi. Azoles sterol 14-demethylase Saccharomyces cerevisiae S288C
2 Atomic structures are available for both Mtb CYP51 and CYP121, revealing modes of azole binding and intriguing mechanistic and structural aspects. Azoles sterol 14-demethylase Saccharomyces cerevisiae S288C