Title : Protein dynamics and imidazole binding in cytochrome P450 enzymes.

Pub. Date : 2006 Dec

PMID : 17073778






1 Functional Relationships(s)
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1 The crystallographic analysis of the deformability of two bacterial P450 active sites associated with the binding of azole (a class of inhibitors with an imidazole or triazole ring that co-ordinates to the haem iron) inhibitors described in the present study illustrates the importance of protein conformational malleability in the binding of imidazole derivatives. Azoles cytochrome P450 family 2 subfamily B member 6 Homo sapiens