Pub. Date : 2006 Dec
PMID : 17070682
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dexamethasone inhibits TRAIL-induced apoptosis of thyroid cancer cells via Bcl-xL induction. | Dexamethasone | BCL2 like 1 | Homo sapiens |
| 2 | In FRO cells DEX stimulated in a time-dependent fashion the expression of Bcl-xL, but not that of Bcl-2, Bax and Bad. | Dexamethasone | BCL2 like 1 | Homo sapiens |
| 3 | In addition, Bcl-xL mRNA was significantly increased in the presence of DEX, suggesting a transcriptional regulation by the steroid. | Dexamethasone | BCL2 like 1 | Homo sapiens |
| 4 | Transfection of the cells with siRNAs against Bcl-xL inhibited both basal and DEX-stimulated Bcl-xL expression and restored apoptosis in TRAIL-stimulated cells treated with DEX. | Dexamethasone | BCL2 like 1 | Homo sapiens |
| 5 | Transfection of the cells with siRNAs against Bcl-xL inhibited both basal and DEX-stimulated Bcl-xL expression and restored apoptosis in TRAIL-stimulated cells treated with DEX. | Dexamethasone | BCL2 like 1 | Homo sapiens |
| 6 | DEX acts via GR activation and up-regulation of the expression of the anti-apoptotic protein Bcl-xL. | Dexamethasone | BCL2 like 1 | Homo sapiens |