Title : Multiple steps determine the overall rate of the reduction of 5alpha-dihydrotestosterone catalyzed by human type 3 3alpha-hydroxysteroid dehydrogenase: implications for the elimination of androgens.

Pub. Date : 2006 Oct 31

PMID : 17059222






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The k(cat) for the NADPH-dependent reduction of DHT catalyzed by AKR1C2 is 0.033 s(-1). NADP aldo-keto reductase family 1 member C2 Homo sapiens
2 Stopped-flow experiments to measure the formation of the AKR1C2.NADP(H) binary complex indicated that two slow isomerization events occur to yield a tight complex. NADP aldo-keto reductase family 1 member C2 Homo sapiens