Pub. Date : 1990 Aug 20
PMID : 1704321
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study the effect of the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA), on the hormonal induction of tyrosinase was examined. | Tetradecanoylphorbol Acetate | tyrosinase | Mus musculus |
| 2 | In this study the effect of the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA), on the hormonal induction of tyrosinase was examined. | Tetradecanoylphorbol Acetate | tyrosinase | Mus musculus |
| 3 | TPA was found to lower basal levels of tyrosinase activity in melanoma cells and to reduce tyrosinase levels in cells treated with either MSH (10(-7) M), dibutyryl cAMP (10(-4) M), isobutylmethylxanthine (IBMX, 10(-4) M), or with the potent MSH analogue, [Nle4,D-phe7]-alpha-MSH. | Tetradecanoylphorbol Acetate | tyrosinase | Mus musculus |
| 4 | TPA was found to lower basal levels of tyrosinase activity in melanoma cells and to reduce tyrosinase levels in cells treated with either MSH (10(-7) M), dibutyryl cAMP (10(-4) M), isobutylmethylxanthine (IBMX, 10(-4) M), or with the potent MSH analogue, [Nle4,D-phe7]-alpha-MSH. | Tetradecanoylphorbol Acetate | tyrosinase | Mus musculus |
| 5 | In order to determine how TPA may reduce tyrosinase activity in melanoma cells, the levels of tyrosinase mRNA in untreated or TPA-treated cells were determined by Northern blot analysis. | Tetradecanoylphorbol Acetate | tyrosinase | Mus musculus |
| 6 | In order to determine how TPA may reduce tyrosinase activity in melanoma cells, the levels of tyrosinase mRNA in untreated or TPA-treated cells were determined by Northern blot analysis. | Tetradecanoylphorbol Acetate | tyrosinase | Mus musculus |
| 7 | Tyrosinase mRNA levels in cultures exposed to TPA for 48 h were only 7% of control levels. | Tetradecanoylphorbol Acetate | tyrosinase | Mus musculus |
| 8 | Tyrosinase mRNA levels in cells treated with both MSH and TPA were also lower than in cells treated with MSH alone. | Tetradecanoylphorbol Acetate | tyrosinase | Mus musculus |