Title : Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation.

Pub. Date : 2006 Dec 15

PMID : 17038311






3 Functional Relationships(s)
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1 Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation. Proline SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens
2 Subsequently, we identified and mutated to alanine four proline-rich motifs in the PTH1R distal C terminus, which resulted in loss of both c-Src and arrestin co-precipitation and significantly decreased ERK1/2 activation. Proline SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens
3 These data delineate the multiple PTH1R structural determinants for ERK1/2 activation and newly identify a unique mechanism involving proline-rich motifs in the receptor C terminus for reciprocal scaffolding of c-Src and beta-arrestin2 with a class II G-protein-coupled receptor. Proline SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens