Pub. Date : 2007 Jan
PMID : 17030072
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We determined: phosphorylation of Janus kinase (JAK) 1 and -2, signal transducer and activator of transcription (STAT)3 and -5, extracellular signal-regulated kinase (ERK)1/2 and p38 by Western blot; H2O2 concentration by a colorimetric method; MMP-1 mRNA levels and stability by Northern blot; MMP-1 promoter activity as well as pro-MMP-1 by ELISA; and active MMP-1 by fluorescence. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | The repression was mediated by JAK/STAT pathway in synergism with JAK-mediated H2O2-dependent ERK1/2 and p38 pathways. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | CONCLUSIONS: Leptin represses MMP-1 gene expression via the synergistic actions of the JAK/STAT pathway and JAK-mediated H2O2-dependent ERK1/2 and p38 pathways. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |