Title : Extracellular generation of hydrogen peroxide is responsible for activation of EGF receptor by ultraviolet A radiation.

Pub. Date : 2006 Nov 1

PMID : 17023275






1 Functional Relationships(s)
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1 In summary, extracellularly generated H(2)O(2) mediates UVA-induced activation of the EGFR and of ErbB2, whereas intracellular generation of reactive oxygen species upon exposure of cells to UVA is not sufficient for activation of the receptor. Hydrogen Peroxide epidermal growth factor receptor Homo sapiens