Title : Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology.

Pub. Date : 2006 Oct

PMID : 17021402






1 Functional Relationships(s)
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1 When primary astrocytes were exposed to fibrillar Abeta in vitro, IDE protein level increased as compared with control, and this effect was reduced by the addition of U0126, a specific inhibitor of the ERK1/2 mitogen-activated protein kinase cascade. U 0126 amyloid beta precursor protein Homo sapiens