Title : Synthesis and evaluation of coumermycin A1 analogues that inhibit the Hsp90 protein folding machinery.

Pub. Date : 2006 Oct 12

PMID : 17020320






1 Functional Relationships(s)
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1 [structure: see text] The coumarin antibiotics are not only potent inhibitors of DNA gyrase but also represent the most effective C-terminal inhibitors of 90 kDa heat shock proteins (Hsp90) reported thus far. coumarin DNA topoisomerase II alpha Homo sapiens