Title : Interactions between oxicams and membrane bilayers: an explanation for their different COX selectivity.

Pub. Date : 2006 Sep

PMID : 17017983






2 Functional Relationships(s)
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1 Meloxicam was launched as a major new NSAID for the treatment of arthritis following extensive published research confirming its selectivity for COX-2. Meloxicam mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 In contrast lornoxicam and meloxicam, which demonstrated activity against COX-2, have revealed smaller partition capacity in liposomes/water systems together with a higher ability to change the membrane fluidity and surface potential. Meloxicam mitochondrially encoded cytochrome c oxidase II Homo sapiens