Title : Drug evaluation: forodesine - PNP inhibitor for the treatment of leukemia, lymphoma and solid tumor.

Pub. Date : 2006 Oct

PMID : 17016779






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Forodesine is a potent PNP inhibitor that acts by elevating plasma 2"-deoxyguanosine (dGuo) and intracellular deoxyguanosine triphosphate, which in turn affects deoxynucleotide-triphosphate pools and induces cell death by apoptosis. deoxyguanosine triphosphate purine nucleoside phosphorylase Homo sapiens